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However, under hypoxic conditions, HIF-1 translocates from your cytosol to the nucleus and heterodimerizes with HIF-1 to form the active HIF-1 protein, binding and activating hypoxia responsive genes, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) (Maxwell and Salnikow, Rey and Semenza, 2004)

However, under hypoxic conditions, HIF-1 translocates from your cytosol to the nucleus and heterodimerizes with HIF-1 to form the active HIF-1 protein, binding and activating…